Lutein derived from Xenostegia tridentata exhibits anticancer activities against A549 lung cancer cells via hyaluronidase inhibition.

Hyaluronidase has been emerging as a potential target for cancer treatment. Herein, the anticancer effects against A549 NSCLC cells and hyaluronidase inhibitory activity of the ethanol extract of Xenostegia tridentata (L.) D.

Bi(OTf)-Catalyzed Cascade Cycloaddition-Decarbonylation--Deoxygenative Aromatization between 2-Arylisatogens and Styrenes: Unveiling a Synthesis of 2,4-Diarylquinolines.

An unprecedented Bi(OTf)-catalyzed reaction between 2-arylisatogens and vinylarenes to yield 2,4-diarylquinolines is reported. The transformation occurred via a Bi-coordination to the embedded anionic nitrone oxygen, which induced a regiospecific stepwise formal [4 + 2]-cycloaddition with vinylarenes to yield a strained tricyclic intermediate, which subsequently extruded gaseous carbon monoxide. -Deoxygenative aromatization ensued to produce 2,4-diarylquinolines.

Chemical profile and biological activities of Lysiphyllum binatum (Blanco) de Wit.

Lysiphyllum binatum (Blanco) de Wit in the Fabaceae family, despite its traditional medicinal uses, has not been the subject of prior scientific inquiry into its chemical and biological profile. The dichloromethane and MeOH extracts of its roots exhibited notably similar antioxidant activity, while the dichloromethane extract of the vine stems showed aromatase inhibition. This study aimed to identify the bioactive components responsible for these activities.

Cascade Cyclization of -(2-Acyl-1-ethynyl)benzaldehydes with Amino Acid Derivatives: Synthesis of Indeno[2,1-]pyran-3-ones and 1-Oxazolonylisobenzofurans via the Erlenmeyer-Plöchl Azlactone Reaction.

A highly regioselective divergent approach is reported for the synthesis of both indeno[2,1-]pyran-3-one and 1-oxazolonylisobenzofuran derivatives using the Erlenmeyer-Plöchl azlactone (EPA) reaction. This approach involves the synthesis of -(2-acyl-1-ethynyl)benzaldehydes, which reacted with various amino acids. Reaction with -acylglycines resulted in the formation of indeno[2,1-]pyran-3-ones, involving the sequential formation of two C-C bonds and two C-O bonds.

Grewiifopenes A-K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent.

Eleven novel clerodane-type diterpenoids, grewiifopenes A-K (1-4 and 12-18), along with nine known compounds (5-11, 19, and 20) were purified from the dichloromethane extract of the twigs and stems of Casearia grewiifolia Vent. (Salicaceae). Their spectroscopic data, including the NMR, HRESIMS, and electronic circular dichroism calculations were employed to completely characterize and elucidate the chemical structures and absolute configurations.