Publications by authors named "S Ruble"
Actively avoiding danger is necessary for survival. Most research on active avoidance has focused on the behavioral and neurobiological processes when individuals learn to avoid alone, within a solitary context. Therefore, little is known about how social context affects active avoidance.
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- Active avoidance is essential for survival, but most studies have focused on how individuals act alone, leaving gaps in understanding the influence of social context on this behavior.
- In experiments with rats, it was found that those trained with a social partner showed more freezing behavior and less active avoidance compared to those trained alone, with notable gender differences in responses under solitary conditions.
- The anterior cingulate cortex (ACC) plays a key role in mediating avoidance responses, and manipulating this brain region affected avoidance differently in males and females, highlighting the need for further research on how these mechanisms differ by sex, especially in relation to anxiety disorders.
Aims: The HeartLogic multisensor index has been found to be a sensitive predictor of worsening heart failure (HF). However, there is limited data on this index's association and its constituent sensors with HF readmissions.
Methods And Results: The PREEMPT-HF study is a global, multicentre, prospective, observational, single-arm, post-market study.
Background: Patients with heart failure (HF) and reduced ejection fraction suffer from a relapsing and remitting disease course, where early treatment changes may improve outcomes. We assessed the clinical integration and safety of the HeartLogic multisensor index and alerts in HF care.
Methods: The Multiple cArdiac seNsors for mAnaGEment of Heart Failure (MANAGE-HF) study enrolled 200 patients with HF and reduced ejection fraction (<35%), New York Heart Association functional class II-III symptoms, implanted with a cardiac resynchronization therapy-defibrillator or and implantable cardioverter defibrillator, who had either a hospitalization for HF within 12 months or unscheduled visit for HF exacerbation within 90 days or an elevated natriuretic peptide concentration (brain natriuretic peptide [BNP] of ≥150 pg/mL or N-terminal pro-BNP [NT-proBNP] of ≥600 pg/mL).