An in vitro bovine pericardial hemocompatibility testing system.

Background And Aims Of The Study: Bovine pericardium has been used as a biomaterial for heart valves since the late 1960s. Cross-linking agents have been applied routinely to reduce host-tissue response, including antigenicity, and to improve tissue leaflet durability. Evaluation of improvements in bovine pericardial valve leaflet calcification and flexibility require that in vitro systems be developed to correlate data with results from in vivo studies.