Detection of human brain cancers using genomic and immune cell characterization of cerebrospinal fluid through CSF-BAM.

Unlabelled: Patients who have radiographically detectable lesions in their brain or other symptoms compatible with brain tumors pose challenges for diagnosis. The only definitive way to diagnose such patients is through brain biopsy, an obviously invasive and dangerous procedure. Here we present a new workflow termed "CSF-BAM" that simultaneously identifies cell or T cell receptor rearrangements, neuploidy, and using PCR-mediated amplification of both strands of the DNA from CSF samples.

Antibody-Based Therapies for Peripheral T-Cell Lymphoma.

While antibody-based immunotherapeutic strategies have revolutionized the treatment of B-cell lymphomas, progress in T-cell lymphomas has suffered from suboptimal targets, disease heterogeneity, and limited effective treatment options. Nonetheless, recent advances in our understanding of T-cell biology, the identification of novel targets, and the emergence of new therapies provide hope for the future. In this review, we explore four areas of current and evolving antibody-based strategies for the treatment of peripheral T-cell lymphoma (PTCL): monoclonal antibodies (mAbs), bispecific antibodies (BsAs), chimeric antigen receptor T-cell therapy (CAR-T), and antibody-drug conjugates (ADCs).

NiO/MnOcoated on carbon felt as an electrode material for supercapacitor applications.

Transition metal oxides have demonstrated excellent capability for charge storage when used in supercapacitor electrodes. This study undertook the hydrothermal synthesis of bimetallic nickel and manganese oxide (NiO/MnO) on a carbon-felt (CF) substrate. NiO/MnO/CF electrode was characterized and examined in a three-electrode system in a potassium hydroxide electrolyte.

Electrochemical oxidation of ethanol on NiO/MoOhybridized wheat husk derived activated carbon.

The ethanol oxidation process in fuel cells is most efficient when conducted by platinum based catalysts. Our research team endeavored to find affordable and efficient catalysts, synthesizing catalysts based on metal oxides of nickel and molybdenum in the form of NiO/MoOand NiO/MoOhybridized with activated carbon obtained from the wheat husk (ACWH) through a hydrothermal method. After precise physical characterization, the capability of these catalysts in the ethanol oxidation process was measured through electrochemical analyses in an alkaline environment.