Publications by authors named "S Roura"
Background: Pragmatic randomized controlled trials are getting more interest to improve trials' external validity. This study aimed to assess how pragmatic the design of the self-labelled pragmatic randomised controlled trials in the manual therapy field is.
Methods: We searched MEDLINE and the Cochrane Central Register of Controlled Trials for self-labelled pragmatic randomised controlled trials in the manual therapy field until January 2024 were included.
Article Synopsis
- - Sacubitril/valsartan (Sac/Val) shows better outcomes than β-blockers in reducing heart failure risks and improving myocardial scar remodeling after a myocardial infarction (MI) in pigs.
- - In a study with 22 pigs post-MI, those treated with β-blocker plus Sac/Val exhibited significant reductions in inflammatory markers, scar mass, and specific types of collagen in the heart.
- - The combination treatment also led to lowered risk of ventricular tachycardia, indicating a potential therapeutic benefit for heart health after MI.
Article Synopsis
- The PERISCOPE Phase I clinical trial assessed the safety of PeriCord, a tissue graft made from decellularised pericardial matrix and umbilical cord mesenchymal cells, in patients undergoing surgical revascularization after non-acute myocardial infarction.
- In the trial, seven patients received PeriCord and demonstrated no adverse effects during the one-year follow-up, although there were no significant changes in overall quality of life or cardiac function compared to controls.
- The study highlighted PeriCord's immunomodulatory effects, specifically in influencing the behavior of circulating monocytes towards a repair-promoting state, indicating potential for further exploration in treating inflammation-related conditions.
Huntington's disease (HD) is an incurable inherited brain disorder characterised by massive degeneration of striatal neurons, which correlates with abnormal accumulation of misfolded mutant huntingtin (mHTT) protein. Research on HD has been hampered by the inability to study early dysfunction and progressive degeneration of human striatal neurons in vivo. To investigate human pathogenesis in a physiologically relevant context, we transplanted human pluripotent stem cell-derived neural progenitor cells (hNPCs) from control and HD patients into the striatum of new-born mice.
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