Design and Synthesis of Red-Absorbing Fluoran Leuco Dyes Supported by Computational Screening.

We report here on the design and synthesis of red-absorbing fluoran leuco dyes (LD). An essential part of the present dye development process is a computational screening of the candidate molecules, which allows for both time-efficient and accurate in silico characterization of the dyes. We focus our study here on the robust benzo[a]fluoran scaffold frequently used in leuco dyes.

Electrostatic Surface Charging by Water Dewetting.

Water dewetting generates static electricity. We reviewed historical experiments of this phenomenon, and we studied the charging of polymer slides and metal electrode supported polymer films withdrawn vertically from a pool of aqueous solutions. For pure water, charging was negative and surface charge densities increased with the speed of dewetting, which we explain by the thermally activated entrainment of nanometer-sized water droplets or clusters charged by unbalanced adsorbed electric double-layer ions.

The ethnobotany, phytochemistry and biological properties of genus Ferulago - A review.

Ethnopharmacological Relevance: The genus Ferulago, belonging to the Apiaceae family, is found mainly in the Mediterranean area, Southwest and Middle Asia, the Caucasus and North Africa. Since ancient times, species of this genus have been largely employed in traditional medicine for their biological properties such as antimicrobial, anti-inflammatory, antispasmodic, insecticidal, and anti-malaria, cholinesterase inhibition effects, etc. AIMS: The scope of this paper is to present a comprehensive respect review of this interesting genus including traditional uses, chemical composition of volatile and non-volatile metabolites, and in vitro and in vivo biological properties either utilizing the crude extracts or essential oils, or the single isolated compounds.

In Vitro Modulation of P-Glycoprotein Activity by Essential Oil on Acute Myeloid Leukemia Cell Line HL-60R.

species have a large spectrum of traditional medicinal uses. We tested the biological activities of the essential oil (EO) of Drake in an acquired multidrug resistance leukemia model to assess whether the EO obtained by hydrodistillation of stems was able to reverse the resistant phenotype. HL-60R cell lines are characterized by the overexpression of P-glycoprotein (P-gp), inhibitors of apoptosis proteins (IAPs) and constitutive expression of NF-κB.

The Essential Oil Compositions of Three Taxa Growing Wild in Sicily: HCA and PCA Analyses.

The chemical composition and the qualitative and quantitative variability of the essential oils of three taxa belonging to the genus were studied. The investigated taxa, that grow wild in Sicily, were L. (section (Mill.