Publications by authors named "S Rivera"
Clearance of residual Host Cell Proteins (HCPs) is critical for the manufacturing processes of biotherapeutics. HCPs have the potential to impact product efficacy and quality, posing a risk to patient safety. It is therefore essential to be able to both identify and quantitate HCPs throughout drug development, even if the proteins are present in low concentrations.
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- Identifying and controlling high-risk host cell proteins (HCPs), especially those with hydrolase activity, is essential for maintaining the quality and shelf life of biotherapeutics, as they can degrade polysorbate excipients used in drug formulations.
- The study optimized an activity-based protein profiling (ABPP) workflow, refining sample preparation parameters and utilizing advanced techniques like PASEF and TIMS to enhance the identification of polysorbate-degradative enzymes (PSDEs).
- The optimized workflow successfully detected PSDEs at very low concentrations (10 ppb) in drug samples and improved detection of enzymes critical for understanding drug degradation issues.
The coronavirus disease 2019 (COVID-19) pandemic had dramatic impacts throughout the United States (US). In Cameron County, Texas, along the Texas-Mexico border, the impacts of the virus were felt more severely than in most places in the US. Residents of the county, which has high rates of poverty, many multigenerational households, high levels of underlying conditions, and an uninsured population of almost 30 percent, were not only poised to be affected by the virus but also by the response policies put in place to contain it.
View Article and Find Full Text PDFEffective governance is crucial for the success of conservation projects aimed at protecting wildlife populations and supporting human well-being. However, few large-scale, comprehensive syntheses have been conducted on the effects of different environmental governance types on conservation outcomes (i.e.
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- Hearing loss in older adults negatively impacts both general health-related quality of life and disease-specific quality of life, often persisting even with the use of hearing aids.
- Active Communication Education (ACE) is a promising group communication program that aims to enhance communication skills and reduce limitations associated with hearing loss, potentially improving overall quality of life.
- A study involving 114 older adult hearing aid users found that those who participated in the ACE program showed significant improvements in various quality of life dimensions, particularly in social relationships and environmental factors, compared to those who received standard informational lectures.