[18F]Tetrafluoroborate: a new NIS PET/CT radiopharmaceutical. An overview focused on differentiated thyroid cancer.

Background: In relapsing differentiated thyroid cancer (DTC), the in vivo evaluation of natrium-iodine symporter (NIS) expression is pivotal in the therapeutic planning and is achieved by [131/123I]Iodine whole-body scan. However, these approaches have low sensitivity due to the low sensitivity due to the low resolution of SPECT. [18F]Tetrafluoroborate (TFB) has been proposed as a viable alternative, which could outperform [131/123I]Iodine scans owing to the superior PET resolution.

Microenvironmental Traits of Classical Hodgkin's Lymphoma in Adolescents and Their Prognostic Impact.

Background: Classical Hodgkin's lymphoma (cHL) in adolescents between 15 and 18 years old shows a higher disease-related mortality, and the overall prognosis is worse than in both children and adults.

Objectives: We investigated the immune checkpoint inhibitors (ICPIs) therapeutic targets and specific T-regulatory and cytotoxic T-cell subsets in the subgroup of adolescent cHL patients, and we challenged their prognostic power.

Methods: We retrieved formalin-fixed paraffin-embedded (FFPE) tissue of adolescent patients diagnosed with cHL and tested by immunohistochemistry the immune checkpoint molecules CTLA-4, LAG-3, PD-1, and PDL1 as well as the biological markers FOXP3 and CD8.

Breaking down the relationship between disruption scores and citation counts.

The emergence of the disruption score provides a new perspective that differs from traditional metrics of citations and novelty in research evaluation. Motivated by current studies on the differences among these metrics, we examine the relationship between disruption scores and citation counts. Intuitively, one would expect disruptive scientific work to be rewarded by high volumes of citations and, symmetrically, impactful work to also be disruptive.

Canine leishmaniasis in Maghreb countries: A systematic review and meta-analysis.

Canine leishmaniasis (CanL) is a zoonotic disease caused by infection with Leishmania infantum and transmitted by female phlebotomine sandflies. It is prevalent in the Mediterranean basin, including the Maghreb region which comprises of Algeria, Tunisia, and Morocco. The environmental conditions in this area provide a suitable habitat for the proliferation of the phlebotomine sandfly, making it an endemic region for CanL.

Immunophenotypic Profile of Adult Glioblastoma IDH-Wildtype Microenvironment: A Cohort Study.

: Glioblastoma -wildtype (GBM -wt) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping its tumor microenvironment (TME) regulate tumor progression and treatment response. The aim of this study was to characterize the main immunosuppressive elements of the GBM -wt TME.