Publications by authors named "S Reznakova"
Thymidylate synthetase (TS) plays a critical role in the de novo synthesis of dTMP inside the cell. Therefore, TS is a suitable target for cytotoxic drugs such as fluoropyrimidines. Drug efficacy and toxicity depend on the intracellular level of TS, which is significantly influenced by the polymorphisms in the 5'UTR (TSER - rs45445694, TSER*3G>C - rs2853542) and 3'UTR (1494del TTAAAG - rs151264360) of TYMS gene.
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- - Autophagy is a crucial process in cancer cells and targeting it may lead to new cancer treatments; this study explores the effects of Schiff base Cu(II) complexes on breast cancer cells and healthy cells.
- - The study found that MCF-7 cancer cells developed resistance to the Cu(II) complexes over time, while non-cancerous HEK-293T cells remained unaffected; significant changes in actin fibers were observed in MCF-7 cells treated with the complexes.
- - Results indicated that the copper complexes promoted autophagy in MCF-7 cells, as evidenced by the production of the LC3 protein after 72 hours, showcasing their potential as anticancer agents.