Publications by authors named "S Rex"
Objectives: Identifying cardiac surgical patients at risk of requiring red blood cell (RBC) transfusion is crucial for optimizing their outcome. We critically appraised prognostic models preoperatively predicting perioperative exposure to RBC transfusion in adult cardiac surgery and summarized model performance.
Methods: Design: Systematic review and meta-analysis.
Background: General anesthesia during pregnancy is not uncommon, for example, for trauma surgery, cerclage, or cesarean delivery. Current recommendations are to maintain maternal partial pressure of carbon dioxide in arterial blood (paCO2) at 30 mm Hg, which is based solely on the average maternal paCO2 in awake pregnant women. However, there is no evidence that this target, compared to other targets, would enable optimal conditions for the fetus during general anesthesia.
View Article and Find Full Text PDFObjective: We aimed to explore the feasibility of an inverted-T upper hemisternotomy approach for pulmonary endarterectomy (PEA) and report the results after 17 cases.
Methods: PEA was conducted through a 7-cm skin incision using an inverted-T upper hemisternotomy across the third intercostal spaces. Cardiopulmonary bypass (CPB) was established through central arterial and percutaneous femoral dual-staged venous cannulation.
The role of a hemoadsorption filter on cytokine levels during 1 hour of thoraco-abdominal normothermic regional perfusion for donation after circulatory death heart donation in a porcine model.
Artif Organs
December 2024
Article Synopsis
- Study Purpose
- : The research aimed to determine if using a hemoadsorption device during thoraco-abdominal normothermic regional perfusion (TA-NRP) in heart donation after circulatory death could reduce inflammation and improve heart function.
- Methodology
- : Involved 15 pigs undergoing induced circulatory arrest, followed by TA-NRP with and without a hemoadsorption device. Plasma cytokine levels were measured at various points, and cardiac function was evaluated using pressure-volume loop analysis.
- Findings
- : The hemoadsorption device did not significantly influence cytokine levels or cardiac function post-TA-NRP, indicating that inflammation levels and heart performance were not improved by this intervention
Background: Cardiac surgery involving cardiopulmonary bypass (CPB) is associated with the risk of acquired coagulopathy, including dysregulated fibrinolysis, which can result in life-threatening bleeding complications. Aprotinin, an antifibrinolytic agent, has been recommended for the prevention of these complications. Its effectiveness has been attributed to its ability to nonspecifically inhibit various serine proteases involved in the coagulation and fibrinolysis cascade.
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