Publications by authors named "S Requena"
Introduction: CD8 cytotoxic T lymphocytes (CTLs) are highly effective in defending against viral infections and tumours. They are activated through the recognition of peptide-MHC-I complex by the T-cell receptor (TCR) and co-stimulation. This cognate interaction promotes the organisation of intimate cell-cell connections that involve cytoskeleton rearrangement to enable effector function and clearance of the target cell.
View Article and Find Full Text PDFPsychotic symptoms can be highly debilitating for those experiencing them. Community members, including family and friends, can play a crucial role in providing support to a person during the early stages of psychosis, provided they have the necessary resources. Mental health first aid guidelines for psychosis have been developed for high-income countries and this study aimed to adapt those guidelines for Brazil.
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- The mitochondrial network's organization significantly impacts T cell metabolism and their response to T cell receptor (TCR) stimulation, requiring dynamic changes in the cytoskeleton.
- Activation signals like TCR and CD28 lead to mitochondrial polarization and movement towards the immune synapse, crucial for T cell function.
- The study emphasizes the role of End-binding protein 1 (EB1) in regulating cytoskeletal structure and mitochondrial arrangement, linking cytoskeleton dynamics to metabolic efficiency and functionality in activated CD4 T cells.