Blood-based tests for multi-cancer early detection (MCED) are being developed to facilitate the detection of various cancer types. The Detecting cancers Earlier Through Elective mutation-based blood Collection and Testing study (DETECT-A) study evaluated an MCED test in 9,911 women, age 65-75, without personal history of cancer. In a analysis, we report on the detection of precancerous neoplasms consequent to MCED testing and follow-up.
View Article and Find Full Text PDFResearchers and environmental managers need big datasets spanning long time periods to accurately assess current and historical water quality conditions in fresh and estuarine waters. Using remote sensing data, we can survey many water bodies simultaneously and evaluate water quality conditions with greater frequency. The combination of existing and historical water quality data with remote sensing imagery into a unified database allows researchers to improve remote sensing algorithms and improves understanding of mechanisms causing blooms.
View Article and Find Full Text PDFA well-documented consequence of global warming is increased psychological distress and climate anxiety, but data gaps limit action. While climate anxiety garners attention, its expression in therapy remains unexplored. Natural language processing (NLP) models can identify climate discussions in therapy, aiding therapists and informing training.
View Article and Find Full Text PDFThe precise neurophysiological changes prompted by meningeal lymphatic dysfunction remain unclear. Here, we showed that inducing meningeal lymphatic vessel ablation in adult mice led to gene expression changes in glial cells, followed by reductions in mature oligodendrocyte numbers and specific lipid species in the brain. These phenomena were accompanied by altered meningeal adaptive immunity and brain myeloid cell activation.
View Article and Find Full Text PDF