Publications by authors named "S Rayner"
Background: Adaptation of the right ventricle is a key determinant of outcomes in pulmonary arterial hypertension (PAH). Despite a compelling rationale to develop targeted therapies for the right ventricle in PAH, no such treatments exist. H-receptor antagonism is a potential myocardial-focused paradigm in heart failure.
View Article and Find Full Text PDFCell-cell fusion has been implicated in various physiological and pathological processes, including cancer progression. This study investigated the role of cell-cell fusion in non-small cell lung cancer (NSCLC), focusing on its contribution to chemoresistance and tumor evolution. By co-culturing drug-sensitive and drug-resistant NSCLC cell lines, we observed spontaneous cell-cell fusion events, particularly under gefitinib selection.
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- - The study investigates the relationship between proteomic features and outcomes related to right ventricular (RV) health in patients with pulmonary arterial hypertension (PAH), focusing on mortality, RV dilation, and NT-proBNP levels.
- - A cohort of 117 PAH participants underwent proteomic profiling, revealing significant differences in protein abundance between survivors and nonsurvivors, as well as between patients with dilated and nondilated RVs, with a notable emphasis on extracellular matrix (ECM) proteins.
- - The findings indicate that specific plasma proteomic profiles correlate with worse clinical outcomes in PAH, suggesting that ECM-related pathways may play a critical role in RV susceptibility to failure, and these results were validated in additional PAH
Introduction: The efficacy of exercise referral schemes (ERS) involving primary care providers to an exercise specialist on patients' physical activity is uncertain and primarily based on self-report outcomes. Cardiorespiratory endurance carries clinically relevant information and is an objective outcome measure that has been used to evaluate ERS, but this literature has not been amalgamated. We determined the effectiveness of ERS involving qualified exercise professionals (QEPs) on patients' cardiorespiratory endurance.
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- * Inpatient biopsies had significantly higher mortality rates (8% at 14 days, 26% at 30 days) compared to outpatient ones (2.2% at 14 days, 8.6% at 30 days), with older and more comorbid patients facing greater risks.
- * Approximately 46% of patients received chemotherapy within six months, influenced by factors like age, sex, and the type of biopsy, highlighting the need for careful risk assessment and potential palliative care involvement in treatment decisions.