Publications by authors named "S Rauz"
Article Synopsis
- Infectious keratitis (IK) is a major cause of corneal blindness worldwide, and the study evaluates the effectiveness of deep learning (DL) in its diagnosis compared to ophthalmologists.
- The systematic review included 35 studies with over 136,000 corneal images, finding that DL had high sensitivity (86.2%-91.6%) and specificity (90.7%-96.3%) for diagnosing IK.
- Results indicate that DL models perform similarly to ophthalmologists in diagnosing IK, but the conclusions should be approached cautiously due to potential biases and the need for further validation in diverse populations.
Article Synopsis
- Early phase clinical trials focus on evaluating the safety and tolerability of new therapies, primarily using investigator and lab results rather than patient feedback.
- A recent expert roundtable brought together 22 stakeholders to discuss the need for a universal patient-reported outcomes (PRO) model in early phase trials and how to effectively incorporate PROs to assess tolerability and guide treatment decisions.
- The discussions yielded key recommendations and identified priority areas for further research on integrating patient feedback into early trials to improve safety and symptom management.
Article Synopsis
- The limbal niche is where special cells that help heal the eye are found, and this study looks at how these cells change as people get older or get sick.
- Researchers used a cool machine called vibrational optical coherence elastography (OCE) to take pictures and measure the stiffness of eye tissues from people aged 4 to 96 years old.
- They found that the limbal areas (called palisades of Vogt) showed changes in size and stiffness, especially in people over 65, compared to younger individuals.
Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately 5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted and cohesive approach that ranges from increased understanding of mechanisms and drivers at the individual and population levels, AMR surveillance, antimicrobial stewardship, improved infection prevention and control measures, and strengthened global policies and funding to development of novel antimicrobial therapeutic strategies. In this rapidly advancing field, this Review provides a concise update on AMR, encompassing epidemiology, evolution, underlying mechanisms (primarily those related to last-line or newer generation of antibiotics), infection prevention and control measures, access to antibiotics, antimicrobial stewardship, AMR surveillance, and emerging non-antibiotic therapeutic approaches.
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- Atopic dermatitis (AD) is a prevalent skin condition that can occur in individuals of any age, and while dupilumab shows promising efficacy as a monoclonal antibody therapy, its use has been linked to a higher occurrence of ocular side effects.
- The British Association of Dermatologists and the Royal College of Ophthalmologists developed guidance on how to manage these dupilumab-related ocular surface disorders (DROSD) after forming a multidisciplinary group to review literature and recommendations.
- Key recommendations include that treatment with dupilumab should not be delayed for most eye issues, hydration drops are not advised as preventive measures, and specific guidance is provided for managing DROSD in both children under 7 and those older, with a focus on