Publications by authors named "S Ratanalert"
Hybrid RNA:DNA origami, in which a long RNA scaffold strand folds into a target nanostructure via thermal annealing with complementary DNA oligos, has only been explored to a limited extent despite its unique potential for biomedical delivery of mRNA, tertiary structure characterization of long RNAs, and fabrication of artificial ribozymes. Here, we investigate design principles of three-dimensional wireframe RNA-scaffolded origami rendered as polyhedra composed of dual-duplex edges. We computationally design, fabricate, and characterize tetrahedra folded from an EGFP-encoding messenger RNA and de Bruijn sequences, an octahedron folded with M13 transcript RNA, and an octahedron and pentagonal bipyramids folded with 23S ribosomal RNA, demonstrating the ability to make diverse polyhedral shapes with distinct structural and functional RNA scaffolds.
View Article and Find Full Text PDFBackground: Genomic-based tools have been used to predict poor prognosis high-grade glioma (HGG). As genetic technologies are not generally available in countries with limited resources, clinical parameters may be still necessary to use in predicting the prognosis of the disease. This study aimed to identify prognostic factors associated with survival of patients with HGG.
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- The study developed two clinical decision rules for predicting intracranial injuries in patients with mild traumatic brain injury (TBI) based on data from a multi-center analysis of 1,164 patients.
- The decision rules included 13 key predictors such as age, mechanism of injury, and various neurological symptoms, demonstrating strong accuracy in identifying the need for CT scans and neurosurgical interventions.
- The developed rules show good calibration and can assist healthcare providers in risk stratification for patients with mild TBI, particularly in low- to middle-income countries.
Prognosis of low-grade glioma are currently determined by genetic markers that are limited in some countries. This study aimed to use clinical parameters to develop a nomogram to predict survival of patients with diffuse astrocytoma (DA) which is the most common type of low-grade glioma. Retrospective data of adult patients with DA from three university hospitals in Thailand were analyzed.
View Article and Find Full Text PDFEarly posttraumatic seizure (PTS) is a significant cause of unfavorable outcomes in traumatic brain injury (TBI). This study was aimed to investigate the incidence and determine a predictive model for early PTS. A prospective cohort study of 484 TBI patients was conducted.
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