Publications by authors named "S Raskovic"
Introduction: The relationship between Systemic lupus erythematosus (SLE) and Epstein-Barr virus (EBV) infection has been suggested for decades, but the underlying mechanism of the EBV influence on SLE development remains to be elucidated.
Methods: The goals of this research, which included 103 SLE patients and 99 controls, were to investigate the association of the parameters of EBV infection and SLE, to explore whether pooled demographic, clinical and EBV markers achieve a more significant effect on SLE development than each of them individually, and to evaluate EBV nuclear antigen 1 (EBNA1) and latent membrane protein 1 (LMP1) gene polymorphisms in isolates from SLE patients.
Results: Comprehensive results related to serological, molecular and sequence markers of EBV infection in SLE patients demonstrated even 24 times higher possibility of having SLE if there is the presence of anti-EBV-EA(D) (early antigen) IgG antibodies (OR=24.
Article Synopsis
- EBV reactivation is common in patients with active systemic lupus erythematosus (SLE), with many transitioning to a latent state after six months.
- A study involving 51 SLE patients found that higher levels of specific antibodies (anti-EA(D) IgM-Abs) are significant predictors for achieving remission and low disease activity in those with mucocutaneous symptoms.
- Additionally, a higher level of the complement protein C3 may help identify active SLE patients who are likely to transition to latent EBV infection, with specific sensitivity and specificity measures reported.
Giant cell arteritis (GCA) is an immune-mediated vasculitis that affects large arteries. It has been hypothesized that viruses may trigger inflammation within the vessel walls. Genetic studies on human leukocyte antigens (HLAs) have previously reported HLA-DRB1*04 as a susceptible allele for GCA and HLA-DRB1*15 as a protective allele for GCA.
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