Publications by authors named "S Rashad"
The tRNA epitranscriptome has been recognized as an important player in mRNA translation regulation. Our knowledge of the role of the tRNA epitranscriptome in fine-tuning translation via codon decoding at tissue or cell levels remains incomplete. We analyzed tRNA expression and modifications as well as codon optimality across seven mouse tissues.
View Article and Find Full Text PDFAlternative splicing (AS) plays an important role in neuronal development, function, and disease. Efforts to analyze the transcriptome of AS in neurons on a wide scale are currently limited. We characterized the transcriptome-wide AS changes in SH-SY5Y neuronal differentiation model, which is widely used to study neuronal function and disorders.
View Article and Find Full Text PDFTransfer RNA (tRNA) modifications play an important role in regulating mRNA translation at the codon level. tRNA modifications can influence codon selection and optimality, thus shifting translation toward specific sets of mRNAs in a dynamic manner. Queuosine (Q) is a tRNA modification occurring at the wobble position.
View Article and Find Full Text PDFArticle Synopsis
- * Using a SH-SY5Y neuronal differentiation model, researchers identified that mature neurons are more sensitive to oxidative stress and ferroptosis, alongside discovering unique mRNA stability patterns specific to neurons.
- * The study identified SEPHS2 as a key neuron stress regulator and SAMD4A as a major player in mRNA stability changes during differentiation, with knockdown of SAMD4A impairing neuronal maturation and response to oxidative stress.