A study of clinical profile and outcome of patients with snake bite-induced acute kidney injury.

Background: Snake bite is a well-known occupational hazard amongst farmers, plantation workers, and other outdoor workers and results in much morbidity and mortality throughout the world. The complications related to kidneys are observed in most patients with snake bites admitted to a hospital. The current study aimed to study the renal involvement in patients with snake bites with reference to clinical features and the time of onset of acute renal failure.

Phosphite mediated molecular editing switch to -C-H alkylation of isoquinolines: emergence of a distinct photochemical [1,3] N to C rearrangement.

The isoquinoline core is present in one of the largest subsets of bioactive natural products. The multifunctional isoquinoline core exerts diverse bioactivity, resulting in the development of numerous isoquinoline-based drugs and molecules that are currently under clinical trials. We developed a new approach for phosphite-mediated [1,2] alkyl migration for an overall -C-H alkylation -alkylation of isoquinoline.

Effect of combination of polyphenols, polysaccharide, and sodium selenite on bortezomib anti-cancer action.

Combinatorial drug delivery has shown promising results over single drug for cancer therapy. Here, we aimed to explore combination of proteasome inhibitor; bortezomib (BTZ) with natural antioxidants (AOs); polyphenols like caffeic acid (CFA), resveratrol (RES), fucoidan (FD), and synthetic AO; sodium selenite (NaSeO) for cellular cytotoxicity in breast cancer cell lines; MCF-7 and MDA MB-231. The combination of RES + BTZ, FD + BTZ, and NaSeO + BTZ showed synergism while CFA showed antagonism with BTZ.

Effective DDoS attack detection in software-defined vehicular networks using statistical flow analysis and machine learning.

Vehicular Networks (VN) utilizing Software Defined Networking (SDN) have garnered significant attention recently, paralleling the advancements in wireless networks. VN are deployed to optimize traffic flow, enhance the driving experience, and ensure road safety. However, VN are vulnerable to Distributed Denial of Service (DDoS) attacks, posing severe threats in the contemporary Internet landscape.

Effect of daytime light intensity on daily behaviours and concurrent hypothalamic gene expressions in migratory redheaded bunting.

Animals use photic cues to time their daily and seasonal activity. The role of photoperiod has been much investigated in seasonal responses, but the role of light intensity is less understood in passerine finches. We investigated if and how daytime light intensity influences photoinduced migratory phenologies and hypothalamic mRNA expressions in a Palearctic-Indian migratory finch, redheaded bunting (Emberiza bruniceps).