Publications by authors named "S Ramon y Cajal"
Article Synopsis
- Accurate quantification of HER2 gene amplification is crucial for predicting treatment response and prognosis in breast cancer, with FISH being the gold standard but having limitations.
- This study explored a novel super-resolution fluorescence microscopy technique to enhance FISH signal visualization and improve HER2 classification based on 14 breast cancer tissue samples.
- Results showed that super-resolution microscopy provided clearer images and improved signal counts, leading to better classification of HER2 FISH statuses, including the detection of previously ambiguous cases.
Formalin, an aqueous solution of formaldehyde, has been the gold standard for fixation of histological samples for over a century. Despite its considerable advantages, growing evidence points to objective toxicity, particularly highlighting its carcinogenicity and mutagenic effects. In 2016, the European Union proposed a ban, but a temporary permission was granted in consideration of its fundamental role in the medical-diagnostic field.
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- * A retrospective analysis of 3,573 laboratory-confirmed ATL cases in Oran from 1985 to 2019 revealed that 92.5% were cutaneous, with a median evolution time of 30 days, while 7.5% were mucosal with a median time of 7 months.
- * The study highlighted that males were affected more frequently (3:1 ratio), with the majority of cases presenting as single cutaneous lesions on exposed
Tegumentary leishmaniasis (TL) is caused by parasites of the genus Leishmania and transmitted by the sandfly species, insects belonging to the order Diptera, family Psychodidae. Historically, the most endemic area of TL in Argentina has been the northern region. The aim of this work was to analyze the presence and temporal variation of TL cases reported between 1985 and 2019 in Colonia Santa Rosa locality, northern Argentina.
View Article and Find Full Text PDFBackground: Cancer metastasis is a deathly process, and a better understanding of the different steps is needed. The shedding of circulating tumor cells (CTCs) and CTC-cluster from the primary tumor, its survival in circulation, and homing are key events of the metastasis cascade. In vitro models of CTCs and in vivo models of metastasis represent an excellent opportunity to delve into the behavior of metastatic cells, to gain understanding on how secondary tumors appear.
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