Publications by authors named "S Ramdave"
Vasculitis is an autoimmune disease defined by inflammation within blood vessels, typically manifesting systemically with multi-organ complications and clinical features. Isolated vasculitis itself, however, is extremely rare and not characteristically based on the pathophysiology of the condition. Whilst there have been cases of isolated vasculitis in large-medium vessels (e.
View Article and Find Full Text PDFBackground: Enzalutamide and lutetium-177 [Lu]Lu-prostate-specific membrane antigen (PSMA)-617 both improve overall survival in patients with metastatic castration-resistant prostate cancer. Androgen and PSMA receptors have a close intracellular relationship, with data suggesting complementary benefit if targeted concurrently. In this study, we assessed the activity and safety of enzalutamide plus adaptive-dosed [Lu]Lu-PSMA-617 versus enzalutamide alone as first-line treatment for metastatic castration-resistant prostate cancer.
View Article and Find Full Text PDFBackground: The TheraP study reported improved prostate-specific antigen responses with lutetium-177 [Lu]Lu-PSMA-617 versus cabazitaxel in men with metastatic castration-resistant prostate cancer progressing after docetaxel. In this Article, we report the secondary outcome of overall survival with mature follow-up, and an updated imaging biomarker analysis. We also report the outcomes of participants excluded due to ineligibility on gallium-68 [Ga]Ga-PSMA-11 and 2-[F]fluoro-2-deoxy-D-glucose (2-[F]FDG) PET-CT.
View Article and Find Full Text PDFArticle Synopsis
- - The study evaluates how multiparametric MRI (mpMRI) and Gallium-68 PSMA PET/CT scans can help in making decisions about salvage therapy for prostate cancer patients experiencing biochemical recurrence after surgery.
- - Out of 117 patients who underwent these scans, about 53% had identifiable lesions, while 47% did not; many of those without lesions either observed or delayed treatment showed promising outcomes.
- - The results emphasize the potential of these imaging techniques to guide timely and appropriate salvage therapy, which may help minimize unnecessary treatments; further larger trials are needed to confirm these findings.