Publications by authors named "S Ramassamy"

Unlabelled: Methotrexate is used to manage moderate to severe psoriasis and psoriatic arthritis. Methotrexate acts by inhibiting the enzymes involved in nucleotide synthesis. Methotrexate polyglutamates (MTXPGs) have a higher potency to inhibit Dihydrofolate reductase (DHFR), 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (ATIC), and thymidylate synthase (TS), compared to naïve methotrexate.

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Article Synopsis
  • A 20-year-old woman with a history of acute myeloid leukemia (AML) in remission developed a painful swelling on her tongue accompanied by fever.
  • Despite normal peripheral blood results, a bone marrow biopsy indicated a possible relapse of AML, and a biopsy of the tongue showed signs of oral myeloid sarcoma.
  • This case emphasizes the importance of checking for hematological malignancy relapse in the bone marrow, even when blood tests appear normal, as it showcases an unusual presentation of myeloid sarcoma.
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