Publications by authors named "S Rajasundaram"
Purpose: To investigate the causal effect of elevated blood pressure on primary open-angle glaucoma (POAG) and POAG endophenotypes.
Methods: Two-sample Mendelian randomization (MR) was performed to investigate the causal effect of elevated systolic blood pressure (SBP) (N = 757,601) and diastolic blood pressure (DBP) (N = 757,601) on intraocular pressure (IOP) (N = 139,555), macular retinal nerve fiber layer (mRNFL) thickness (N = 33,129), ganglion cell complex (GCC) thickness (N = 33,129), vertical cup-to-disc ratio (VCDR) (N = 111,724), and POAG liability (Ncases = 16,677, Ncontrols = 199,580). The primary analysis was conducted using the inverse-variance weighted approach.
Article Synopsis
- - Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness, with its underlying causes still not fully understood, particularly in patients with normal intraocular pressure (IOP).
- - Genome-wide association studies (GWAS) identified over 240 loci related to POAG and IOP, revealing significant genes involved in pathways such as extracellular matrix organization and cell adhesion.
- - Single-nucleus RNA sequencing in relevant eye tissues highlighted that the identified genes are concentrated in specific cell types within the aqueous outflow pathways and other critical areas, suggesting both IOP-dependent and independent factors in POAG development.
Objective: To investigate the association of genetically proxied (using a surrogate biomarker) inhibition of phosphodiesterase 5 (PDE5), an established drug target for erectile dysfunction, with fertility, sexual behaviour, and subjective wellbeing.
Design: Two sample cis-mendelian randomisation study.
Setting: Summary data on genetic associations obtained from the International Consortium for Blood Pressure and UK Biobank.
Background: In primary open-angle glaucoma (POAG), lowering intraocular pressure (IOP) is the only proven way of slowing vision loss. Schlemm's canal (SC) is a hybrid vascular and lymphatic vessel that mediates aqueous humour drainage from the anterior ocular chamber. Animal studies support the importance of SC endothelial angiopoietin-TEK signalling, and more recently TIE1 signalling, in maintaining normal IOP.
View Article and Find Full Text PDFObservational studies have shown an association between post-traumatic stress disorder (PTSD) and ischemic stroke (IS) but given the susceptibility to confounding it is unclear if these associations represent causal effects. Mendelian randomization (MR) facilitates causal inference that is robust to the influence of confounding. Using two sample MR, we investigated the causal effect of genetic liability to PTSD on IS risk.
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