Formal [4 + 2] combined ionic and radical approach of vinylogous enaminonitriles to access highly substituted sulfonyl pyridazines.

Pyridazine derivatives hold significant interest due to their broad applications in pharmaceuticals and materials science, where they serve as valuable scaffolds for bioactive compounds and functional materials. Here, we report a formal [4 + 2] reaction for the synthesis of 5'-sulfonyl-4'-aryl-3-cyano substituted pyridazine compounds from the reaction between vinylogous enaminonitriles and sulfonyl hydrazides. The key features of our pyridazine synthesis include the transamidation of vinylogous enaminonitriles with sulfonyl hydrazide, radical sulfonylation of the resulting intermediate, and subsequent 6-endo-trig radical cyclization.

Development and Cross-Cultural Adaptation of the Tamil Version of the Stroke-Specific Quality of Life Scale (SSQoL) and Assessment of its Reliability and Validity.

Background: In this current modern industrial world, strokes are the major reason for causing disability and death in the adult population. In spite of the various tools available to measure the physical, psychological, and social impact of strokes, the appropriate method in various languages around the world is not available. In that sense adapting the Stroke-Specific Quality of Life Scale (SSQoL) in different languages and cultures is essential to ensure their validity and efficacy across diverse populations.

ZW sex chromosome structure in Amborella trichopoda.

Sex chromosomes have evolved hundreds of times across the flowering plant tree of life; their recent origins in some members of this clade can shed light on the early consequences of suppressed recombination, a crucial step in sex chromosome evolution. Amborella trichopoda, the sole species of a lineage that is sister to all other extant flowering plants, is dioecious with a young ZW sex determination system. Here we present a haplotype-resolved genome assembly, including highly contiguous assemblies of the Z and W chromosomes.

Development and Assessment of a Multipurpose Herbal Cream With Moringa oleifera Lam.

Background: Lam. (Moringaceae) is an indigenous tree extensively used as a nutrient and an antioxidant. In addition to its medicinal attributes, it possesses a promising role in moisturizing and cleansing the skin.