A Therapeutic Approach of Chitosan-loaded p-Coumaric Acid Nanoparticles to Alleviate Diabetic Nephropathy in Wister Rats.

Objective: This study evaluated the renoprotective effects of p-Coumaric acid nanoparticles (PCNPs) in nephropathic rats.

Methods: Six groups of male Albino Wistar rats were randomly assigned. Group 1 was the control, while Group 2 received 45 mg/kg of streptozotocin (STZ) to induce diabetic nephropathy.

Enhanced assessment of water quality for both nitrate and nitrite using engineered E. coli with para-aminobenzoic acid biosynthesis.

Background: Monitoring nitrate and nitrite levels in water is vital for protecting human health, aquatic ecosystems, and regulatory compliance. However, traditional detection methods often involve environmentally harmful chemicals. This study introduces a sustainable alternative by leveraging metabolically engineered E.

Dual-functional PCN-242 (FeCo) MOF for sensitive bacterial endotoxin detection.

Endotoxin detection is paramount for monitoring bacterial contamination in food, pharmaceuticals, and clinical diagnostics. The limulus amebocyte lysate (LAL) test, which relies on horseshoe crab blood, has long been the gold standard for endotoxin detection. However, the widespread adoption of this method is constrained by ethical concerns and the high costs associated with harvesting endangered species.

A Cu-based metal-organic framework synthesized a green method exhibits unique catecholase-like activity for epigallocatechin gallate detection in teas.

Tea contains various antioxidant compounds, including polyphenols, catechins, theaflavins, theasinensins, and flavonoids. Among these, epigallocatechin gallate (EGCG) is a crucial antioxidant recognized for its potent bioactivity. This study presents the synthesis of a highly selective Cu-PyC NH-based metal-organic framework (MOF) nanozyme that exhibits catecholase-like activity to assess the antioxidant capabilities of EGCG.

Defect Induced Structural Transition and Lipase Immobilization in Mesoporous Aluminum Metal-Organic Frameworks.

The transition from disorder to order and structural transformation are distinctive metal-organic framework (MOF) features. How to adapt or control both behaviors in MOF has rarely been studied. In this case, we demonstrate that our successful synthesis of [Al(OH)(PDA)]n (AlPDA-53-DEF, AlPDA-53-H, and AlPDA-68) with HPDA=4,4'-[1,4-phenylenebis(ethyne-2,1-diyl)]-di benzoic acid has shown the intricate world of Aluminum Metal-Organic Frameworks (Al-MOFs).