Publications by authors named "S Raja Laskar"
Background: The aim of this study was to document the incidence, spectrum and outcomes of Second Primary Malignancy (SPM) in a prospectively followed-up population of Head and Neck Squamous carcinoma (HNSCC) patients accrued in six prospective trials and treated with definitive radiotherapy.
Materials And Methods: Patients were prospectively followed up over time and data on SPM collected after IRB approval after establishing the diagnosis of SPM based on clinical criteria. Descriptive statistics to determine clinic demographic characteristics and spectrum of SPM encountered, time to event outcomes (SPM-DFS - Disease-free survival after diagnosis of second primary, SPM-OS - Overall survival after diagnosis of second primary) and univariate analysis of factors of likely prognostic significance were performed.
Purpose: Comprehensive Quality Assurance (QA) protocols are necessary for complex beam delivery systems like Pencil Beam Scanning (PBS) proton therapy. This study focuses on automating the evaluation of beam delivery accuracy using irradiation log files and machine learning (ML) models.
Methods: Irradiation log files of 935 clinical treatment fields and routine QA beams were analysed to evaluate spot parameters and Monitor Unit (MU) accuracy.
Can dysphagia aspiration related structures (DARS) be spared in patients with oropharyngeal cancers? Dosimetric evaluation in a prospective study of DARS optimized intensity modulated radiation therapy.
J Cancer Res Ther
July 2024
Article Synopsis
- - The study aimed to assess whether it is possible to protect the structures involved in swallowing and aspiration (DARS) during radiation therapy for head and neck cancer, while still effectively treating the tumors.
- - Researchers outlined specific target areas and dose limits for DARS in 35 patients, finding that the average dose received by these critical structures varied depending on the type of cancer and the size of the tumor volume.
- - Results indicated that sparing DARS was more difficult for patients with oropharyngeal cancers compared to laryngopharyngeal cancers, but it was achievable when the tumor volume was less than 150 cc or in patients with no or only one affected lymph node.
Background: This study reports the psychometric properties of OUTPASAT-35RT questionnaire from a large Indian cancer cohort treated with ambulatory radiotherapy (RT) at a tertiary-care comprehensive cancer center.
Materials And Methods: Adults with a pathologically proven diagnosis of cancer undergoing fractionated RT (≥10 fractions) with the ability to read and understand English, Hindi, or Marathi were accrued after written informed consent. Patients were administered a language-appropriate version of OUTPATSAT-35RT along with European Organization for Research and Treatment of Cancer (EORTC) generic quality-of-life questionnaire (QLQ-C30) at conclusion of RT (±3 days).
Article Synopsis
- Juvenile myoclonic epilepsy (JME) is a genetic generalized epilepsy syndrome that is generally well-controlled, but long-term outcomes can vary due to related personality traits and psychiatric disorders; quality of life (QoL) information in adolescents with JME is limited.
- This study involved 50 participants aged over 11 years, who were assessed using specific quality of life questionnaires (QOLIE-AD-48 for adolescents and QOLIE-31-P for adults) and screened for psychiatric disorders, to understand the impact on their overall quality of life.
- Results showed that while the overall QoL scores were fair for both adults (62.29) and adolescents (69.71), specific areas such