Publications by authors named "S Rahgozar"
Background: Ubiquitin-specific peptidases (USPs), also known as deubiquitinating enzymes (DUBs), play a crucial role in maintaining cellular homeostasis by selectively removing ubiquitin molecules from targeted proteins. This process affects protein stability, subcellular localization, and activity, thereby influencing processes such as DNA repair, cell cycle regulation, and apoptosis. Abnormal USP activities have been linked to various diseases, including cancer.
View Article and Find Full Text PDFDoublecortin (DCX) is a microtubule (MT)-associated protein in immature neurons. DCX is essential for early brain development, and DCX mutations account for nearly a quarter of all cases of lissencephaly-spectrum brain malformations that arise from a neuronal migration failure through the developing cortex. By analyzing pathogenic DCX missense mutations in non-neuronal cells, we show that disruption of MT binding is central to DCX pathology.
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- The study investigates the effects of sex on short-term and postoperative outcomes after thoracic endovascular aortic repair (TEVAR) in patients with thoracic and thoracoabdominal aneurysms, focusing on data from a Medicare-linked database.
- It highlights that female patients tend to have smaller aortic diameters but higher aneurysm growth rates compared to males, suggesting potential complications in the postoperative period.
- The analysis found significant differences in patient characteristics between genders, with females more likely to have certain chronic conditions and be symptomatic upon presentation, while males were more likely to be on preoperative medications.
Background: Leukemia, a type of blood cell cancer, is categorized by the type of white blood cells affected (lymphocytes or myeloid cells) and disease progression (acute or chronic). In 2020, it ranked 15th among the most diagnosed cancers and 11th in cancer-related deaths globally, with 474,519 new cases and 311,594 deaths (GLOBOCAN2020). Research into leukemia's development mechanisms may lead to new treatments.
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