Publications by authors named "S Rahelinirina"

Plague, a zoonotic disease caused by Yersinia pestis, remains a major public health threat in several parts of the world, including Madagascar. Factors underlying long-term persistence and emergence of the pathogen remain poorly understood. We implemented a longitudinal survey to provide insights into plague reservoir ecology within an endemic focus.

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Plague is a zoonotic disease caused by , and it is endemic in Madagascar. The plague cycle involves wild and commensal rodents and their fleas; humans are an accidental host. Madagascar is the country where plague burden is the highest.

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Article Synopsis
  • Pneumonic plague (PP) is highly infectious and spreads quickly from person to person, with a significant outbreak occurring in two urban areas of Madagascar (Antananarivo and Toamasina) in 2017.
  • The research utilized epidemiological data and genomic analysis of Yersinia pestis to trace the sources of this epidemic, noting that human plague cases emerged from environmental reservoirs more than 20 times between August and November 2017.
  • The study revealed that multiple strains of Y. pestis were introduced to urban areas through infected individuals traveling from rural regions, leading to sustained PP transmission, especially in Antananarivo.
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Bubonic plague, transmitted by infected flea bites, is the most common form of plague and, left untreated, can progress to the pneumonic form, which is highly contagious. Surveillance focusing on reservoir and vector is considered to be the main approach to prevent plague. Common rodent control methods include the use of rodenticide and snap traps but, in a plague context, the dispersal of fleas from killed animals may pose a serious health threat.

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Plague is a zoonotic vector-borne disease caused by the bacterium Yersinia pestis. In Madagascar, it persists in identified foci, where it is a threat to public health generally from September to April. A more complete understanding of how the disease persists could guide control strategies.

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