Publications by authors named "S Radian"
High mortality risk among women with acromegaly still persists.
Front Endocrinol (Lausanne)
March 2024
Article Synopsis
- The study analyzed mortality rates in patients with acromegaly over the past few decades, finding an overall improvement and identifying factors related to mortality before and after the implementation of treatment protocols.
- A total of 399 patients were reviewed, with 31.07% cured and a significant but low mortality rate (0.017%) during an average follow-up of 13 years, indicating that factors like hormone levels and surgical treatment are crucial to survival.
- Sex differences were observed, showing higher mortality risks for females (SMR = 1.63) compared to males (SMR = 0.99), with females diagnosed earlier having the highest ratios.
Background/aim: The histopathological variability of each type of pituitary adenoma (PA) that causes growth hormone (GH) excess influences the phenotype, radiological characteristics and therapy response of acromegaly patients. We correlated the immunohistochemical (IHC) features of GH-secreting PAs with their clinical, laboratory and imaging data.
Patients And Methods: We included 32 patients with documented acromegaly; tumour specimens were histologically and IHC examined: anterior pituitary hormones, pituitary-specific transcription factor-1 (PIT-1), Ki-67 labelling index were evaluated.
Introduction: In Romania, there is no acromegaly national register and there are no nationwide data available. However, some studies have reported the control rates in the country's main referral centres. Our aim was to assess the overall control rate in our tertiary referral centre.
View Article and Find Full Text PDFBackground: Heterozygous germline loss-of-function mutations in the aryl hydrocarbon receptor-interacting protein gene () predispose to childhood-onset pituitary tumours. The pathogenicity of missense variants may pose difficulties for genetic counselling and family follow-up.
Objective: To develop an o system to test the pathogenicity of human mutations using the fruit fly .
Introduction: Semaphorin-4D (CD100), generated by CD4/CD8 T-cells and its receptor on B cells - CD72, play a role in immune regulation. Both have soluble forms - sCD100/sCD72.
Methods: sCD100 and sCD72 levels were determined by ELISA (MyBioSource, USA).