Cognitive decline and dementia are a growing problem as the population ages. Effective therapies to prevent and treat these problems are limited. Neuro-inflammation has been suggested as a cause of dementia [1].
View Article and Find Full Text PDFIn tackling the obesity pandemic, considerable efforts are devoted to the development of effective weight reduction strategies, yet many dieting individuals fail to maintain a long-term weight reduction, and instead undergo excessive weight regain cycles. The mechanisms driving recurrent post-dieting obesity remain largely elusive. Here we identify an intestinal microbiome signature that persists after successful dieting of obese mice and contributes to faster weight regain and metabolic aberrations upon re-exposure to obesity-promoting conditions.
View Article and Find Full Text PDFBackground: Non-alcoholic fatty liver (NAFLD) is a common, multi-factorial, and poorly understood liver disease whose incidence is globally rising. NAFLD is generally asymptomatic and associated with other manifestations of the metabolic syndrome. Yet, up to 25% of NAFLD patients develop a progressive inflammatory liver disease termed non-alcoholic steatohepatitis (NASH) that may progress towards cirrhosis, hepatocellular carcinoma, and the need for liver transplantation.
View Article and Find Full Text PDFEnviron Health Perspect
December 1997
Study of the childhood incidence of cancer and other diseases in Belarus is of great importance because of the present unfavorable environmental situation. About 20% of the children in the republic were exposed in various degrees to radiation as a result of the Chernobyl accident. Since 1987 increases in the incidence of most classes of disease have been reported, including the development of thyroid cancer.
View Article and Find Full Text PDF