Publications by authors named "S ROSNER"
Background: Maternity care access is worsening across the United States, driven in part by difficulties staffing obstetric units in some hospitals. Certified registered nurse anesthetists (CRNAs) provide obstetric anesthesia services in underserved areas, including rural areas (Cohen et al., 2021; Martsolf et al.
View Article and Find Full Text PDFModern pharmacotherapy guidance for treating alcohol use disorders.
Expert Opin Pharmacother
December 2024
Introduction: Alcohol use disorder (AUD) is prevalent and recognized as a chronic, relapsing disorder. Even though effective treatment options are available, AUD is strongly undertreated. As adjuvant treatment strategies accompanying psychosocial treatments, pharmacological strategies can increase the efficacy of AUD treatment options.
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- Co-mutations of KRAS and STK11 genes in advanced non-small cell lung cancer (NSCLC) are linked to resistance against immune checkpoint blockade (ICB) therapies, although their impact in patients receiving neoadjuvant chemoimmunotherapy remains unclear.
- A study investigated how these gene mutations affect recurrence-free survival in resectable KRAS-mutated NSCLC, revealing that those with co-occurring STK11 mutations had a higher risk of recurrence compared to those without.
- Analysis of tumor-infiltrating T cells indicated that the presence of STK11 mutations altered T cell behavior, suggesting that certain T cell characteristics might hinder effective anti-tumor immune responses in patients with KRASmut/STK11
Article Synopsis
- Hereditary transthyretin-related amyloidosis (hATTR amyloidosis) is a genetic disease caused by mutations in the transthyretin gene, impacting patients in diverse ways; this study examines the demographics, clinical features, and genetic variants of suspected hATTR cases among 3,167 participants.
- The research identified five key clinical phenotypes linked to 22 symptoms, with a focus on polyneuropathy and cardiomyopathy; it also determined gender differences in symptom presentation.
- Of the participants, 92 were diagnosed with hATTR (3%) having 17 unique genetic variants, predominantly the p.Val50Met variant; in contrast, 503 participants had wild-type
Introduction: Drought-induced embolism formation in conifers is associated with several tracheid and pit traits, which vary in parallel from stem apex to base. We tested whether this axial anatomical variability is associated with a progressive variation in embolism vulnerability along the stem from apex to base.
Methods: We assessed the tracheid hydraulic diameter (), mean pit membrane area () and the xylem pressure at 50% loss of conductivity () on longitudinal stem segments extracted at different distances from the stem apex () in a and an tree.