Publications by authors named "S R Zamuner"
Effect of photobiomodulation in the balance between effector and regulatory T cells in an experimental model of COPD.
Front Med (Lausanne)
June 2024
Article Synopsis
- Chronic Obstructive Pulmonary Disease (COPD) significantly affects global health, with factors such as smoking and immune cell profiles contributing to its severity; a deficiency in specific regulatory T cells can worsen respiratory issues.
- Researchers employed Photobiomodulation (PBM) therapy to investigate its effects on immune response in a COPD mouse model by analyzing various immune cell types and cytokine production.
- The findings indicated that PBM therapy alleviated COPD symptoms by reducing inflammatory immune cell counts, lowering pro-inflammatory cytokines like IFN-γ, and boosting the anti-inflammatory cytokine IL-10, suggesting a potential treatment avenue for COPD.
Photobiomodulation mitigates Bothrops jararacussu venom-induced damage in myoblast cells by enhancing myogenic factors and reducing cytokine production.
PLoS Negl Trop Dis
May 2024
Background: Photobiomodulation has exhibited promise in mitigating the local effects induced by Bothrops snakebite envenoming; however, the mechanisms underlying this protection are not yet fully understood. Herein, the effectiveness of photobiomodulation effects on regenerative response of C2C12 myoblast cells following exposure to Bothrops jararacussu venom (BjsuV), as well as the mechanisms involved was investigated.
Methodology/principal Findings: C2C12 myoblast cells were exposed to BjsuV (12.
Necrosis is common in skin flap surgeries. Photobiomodulation, a noninvasive and effective technique, holds the potential to enhance microcirculation and neovascularization. As such, it has emerged as a viable approach for mitigating the occurrence of skin flap necrosis.
View Article and Find Full Text PDFImportance: Bothrops venom acts almost immediately at the bite site and causes tissue damage.
Objective: To investigate the feasibility and explore the safety and efficacy of low-level laser therapy (LLLT) in reducing the local manifestations of B atrox envenomations.
Design, Setting, And Participants: This was a double-blind randomized clinical trial conducted at Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, in Manaus, Brazil.
The 70-kD heat shock protein (Hsp70) chaperone system is a central hub of the proteostasis network that helps maintain protein homeostasis in all organisms. The recruitment of Hsp70 to perform different and specific cellular functions is regulated by the J-domain protein (JDP) co-chaperone family carrying the small namesake J-domain, required to interact and drive the ATPase cycle of Hsp70s. Besides the J-domain, prokaryotic and eukaryotic JDPs display a staggering diversity in domain architecture, function, and cellular localization.
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