Single-Atom Iridium-doped Carbon Dots Nanozyme with High Peroxidase-Like Activity as Colorimetric Sensors for Multimodal Detection of Mercury Ions.

Nanozyme-based colorimetric sensors are promising approaches for environmental monitoring, food safety, and medical diagnostics. However, developing novel nanozymes that exhibit high catalytic activity, good dispersion in aqueous solution, high sensitivity, selectivity, and stability is challenging. In this study, for the first time, single-atom iridium-doped carbon dot nanozymes (SA Ir-CDs) are synthesized via a simple in situ pyrolysis process.

Design of Fluorinated Peptides as Biotransformed Urinalysis Biomarkers for Non-Invasive Diagnosis and Treatment of Liver Injury through Enzyme Directed Kinetics.

Urinalysis, as a non-invasive and efficient diagnostic method, is very important but faces great challenges due to the complex compositions of urine and limited naturally occurring biomarkers for diseases. Herein, by leveraging the intrinsic absence of endogenous fluorinated interference, a strategy with the enzymatically activated assembly of synthetic fluorinated peptide for cholestatic liver injury (CLI) diagnosis and treatment through F nuclear magnetic resonance (NMR) urinalysis and efficient drug retention is developed. Specifically, alkaline phosphatase (ALP), overexpressed in the liver of CLI mice, triggers the assembly of fluorinated peptide, thus, directing the traffic and dynamic distribution of the synthetic biomarkers after administration, whereas CLI mice display much slower clearance of peptides through urine as compared with healthy counterparts.

Distinct structural and functional heterochromatin partitioning of lamin B1 and lamin B2 revealed using genome-wide nicking enzyme epitope targeted DNA sequencing.

Gene expression is regulated by chromatin DNA methylation and other features, including histone post-translational modifications (PTMs), chromatin remodelers and transcription factor occupancy. A complete understanding of gene regulation will require the mapping of these chromatin features in small cell number samples. Here we describe a novel genome-wide chromatin profiling technology, named as Nicking Enzyme Epitope targeted DNA sequencing (NEED-seq).

Ambient-pressure selective hydrogenation of unsaturated aldehydes and ketones into unsaturated alcohols in the water phase.

A universal and green catalytic system for the hydrogenation of unsaturated aldehydes and ketones into the corresponding alcohols with the CC bonds retained under atmospheric hydrogen pressure in the water phase was realized by -functionalized amino ligand-stabilized ruthenium complexes (-PPhCHNHMe)[(CHNHR)]RuCl (R = H, Me, Et) and (-PPhCHNMe)[(CHNHEt)]RuCl with wide substrate compatibility and excellent functionality tolerance. The structural synergism between -PPhCHNHMe and (CHNHEt) achieves the enhanced performance, with a positive correlation with the electron density of the amino ligand.

Enhancing Droplet Spreading on a Hydrophobic Plant Surface by Surfactant/Cellulose Nanocrystal Complexes.

A surfactant is an efficient and common additive used to enhance the spreading of droplets on hydrophobic surfaces. However, a high surfactant concentration is required to achieve the desired performance, resulting in environmental pollution and increased costs. Additionally, the pesticide loading capacity of surfactants at low concentrations (below their critical micelle concentrations) is a concern.