Publications by authors named "S R Vasa"

The objective was to evaluate the effect of providing dry pelleted starter diet (DPS) or a liquid mixture of milk replacer and starter diet (LMR+S) to suckling pigs housed in farrowing pens of sub-standard or optimal hygiene conditions on pig growth to slaughter, and post-weaning (PW) intestinal parameters. On day (d) 107 of gestation, 87 sows were randomly allocated to one of four treatments in a 2×2 factorial arrangement. The factors were creep feeding (DPS or LMR+S) and pre-farrowing hygiene routine (SUB-STANDARD or OPTIMAL).

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates the genetic connections between endometrial cancer (EC), endometriosis (ENDO), and obesity (OBY) to identify potential therapeutic targets by analyzing gene expression data.
  • - A total of 26 shared differentially expressed genes were found, with IGF-1, CREBBP, EP300, and PIAS1 being key genes linked to disease mechanisms and survival outcomes.
  • - Elevated IGF-1 levels in EC patients are associated with worse survival rates, indicating it may serve as a prognostic marker and highlighting the need for targeted therapies based on genetic findings.
View Article and Find Full Text PDF
Article Synopsis
  • - Visceral obesity (VO) is linked to increased risks for both benign uterine leiomyoma (ULM) and malignant uterine leiomyosarcoma (ULS), but the specific molecular mechanisms connecting these conditions remain largely unknown.
  • - This study used bioinformatics to analyze gene expression data and found 37 overlapping differentially expressed genes (DEGs) among VO, ULM, and ULS, with implications for cell proliferation and immune responses.
  • - The research identified 14 key hub genes, including TOP2A, APOE, and TYMS, and revealed 26 FDA-approved drugs that could potentially target these genes, suggesting new avenues for treatment that need further experimental validation.
View Article and Find Full Text PDF

Reduced piglet feed intake immediately postweaning (pw) leads to disruption of small intestine structure and function and reduced growth. Our objective was to evaluate the effect of providing supplemental milk or liquid starter diet for either 4 or 11 days pw, on intestinal parameters of newly weaned piglets and growth to slaughter. At weaning (28 ± 0.

View Article and Find Full Text PDF

Motional properties of proteins govern recognition, catalysis, and regulation. The dynamics of tightly interacting residues can form intramolecular dynamic networks, dependencies fine-tuned by evolution to optimize a plethora of functional aspects. The constructive interaction of residues from different proteins to assemble intermolecular dynamic networks is a similarly likely case but has escaped thorough experimental assessment due to interfering association/dissociation dynamics.

View Article and Find Full Text PDF