Tenascins Interfere With Remyelination in an Ex Vivo Cerebellar Explant Model of Demyelination.

Oligodendrocytes form myelin membranes and thereby secure the insulation of axons and the rapid conduction of action potentials. Diseases such as multiple sclerosis highlight the importance of this glial cell population for brain function. In the adult brain, efficient remyelination following the damage to oligodendrocytes is compromised.

Effect of cinnamaldehyde on feed intake, rumen fermentation, and nutrient digestibility, in lactating dairy cows1.

The objective of this study was to evaluate the effect of cinnamaldehyde, on feed intake, rumen fermentation, nutrient digestibility, milk yield, and components in lactating dairy cows. Six lactating Holstein dairy cows (3 ruminally cannulated and 3 noncannulated) averaging 263 ± 41 d in milk (DIM) and 754 ± 45 kg of BW at the beginning of the study were used. Cows were randomly assigned to 1 of 3 treatments in a replicated 3 × 3 Latin square design with 19 d periods (14 d for diet adaptation and 5 d for sample collection).

The impact of direct-fed microbials and enzymes on the health and performance of dairy cows with emphasis on colostrum quality and serum immunoglobulin concentrations in calves.

Thirty-six cows were blocked by calving date and randomly assigned to one of three treatments. Cows were on treatments 3 weeks prepartum through 8 weeks post-partum. Treatments were as follows: (i) no direct-fed microbial (DFM) or cellulase and amylase enzymes (C), (ii) 45.

Fluorogen activating protein-affibody probes: modular, no-wash measurement of epidermal growth factor receptors.

Fluorescence is essential for dynamic live cell imaging, and affinity reagents are required for quantification of endogenous proteins. Various fluorescent dyes can report on different aspects of biological trafficking, but must be independently conjugated to affinity reagents and characterized for specific biological readouts. Here we present the characterization of a new modular platform for small anti-EGFR affinity probes for studying rapid changes in receptor pools.

A designed equine herpes thymidine kinase (EHV4 TK) variant improves ganciclovir-induced cell-killing.

The limitations of the ganciclovir (GCV)/herpes simplex virus thymidine kinase (HSV1 TK: EC 2.7.1.