Publications by authors named "S R Unda"
Here, we report a magnetogenetic system, based on a single anti-ferritin nanobody-TRPV1 receptor fusion protein, which regulated neuronal activity when exposed to magnetic fields. Adeno-associated virus (AAV)-mediated delivery of a floxed nanobody-TRPV1 into the striatum of adenosine-2a receptor-Cre drivers resulted in motor freezing when placed in a magnetic resonance imaging machine or adjacent to a transcranial magnetic stimulation device. Functional imaging and fiber photometry confirmed activation in response to magnetic fields.
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- Scientists studied a gene called PGK1, which is important for brain cells to make energy.
- They found that increasing PGK1 can help brain cells work better and protect them from problems caused by Parkinson's disease.
- This research suggests that fixing energy issues in brain cells might be a good way to help treat Parkinson's disease in the future.
Introduction: Delayed Cerebral Ischemia (DCI) is a significant complication following aneurysmal subarachnoid hemorrhage (aSAH) that can lead to poor outcomes. Machine learning techniques have shown promise in predicting DCI and improving risk stratification.
Methods: In this study, we aimed to develop machine learning models to predict the occurrence of DCI in patients with aSAH.
Post-abortion care (PAC) counselling and the provision of contraceptive methods are core components of PAC services. Nevertheless, this service is not uniformly provided to PAC patients. This paper explores the factors contributing to young women leaving health facilities without counselling and contraceptive methods.
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- PGK1 is an enzyme that helps produce energy in cells and is being studied as a way to help treat Parkinson's Disease.
- Research shows that boosting the activity of PGK1 in brain cells can protect against problems caused by the disease.
- Scientists found that issues with energy production in nerve cells may be a key reason why some people are more likely to get Parkinson's, making PGK1 an important target for new treatments.