Publications by authors named "S R Thaller"
Giant cell tumors (GCTs) are benign but locally aggressive bone neoplasms that primarily affect skeletally mature individuals. They are characterized by a tendency for recurrence and being associated with significant morbidity. Traditional treatment has focused on surgical resection; however, the role of medical therapies, such as Denosumab, a bone anti-resorptive drug, which has been Food and Drug Administration (FDA)-approved for unresectable GCTs since 2013, recently has gained prominence.
View Article and Find Full Text PDFIntroduction: Plastic surgery played a crucial role during the World Wars. Surgeons dedicated their careers to reconstructing facial injuries and residual deformities incurred during combat. Times of unprecedented trauma led to rapid innovation in plastic surgery, with invaluable impact on practice today.
View Article and Find Full Text PDFVenous leg ulcers (VLUs) represent one of the most prevalent types of chronic wounds characterised by perturbed microbiome and biofilm-forming bacteria. As one of the most abundant skin-commensal, Staphylococcus epidermidis is known as beneficial for the host, however, some strains can form biofilms and hinder wound healing. In this study, S.
View Article and Find Full Text PDFArticle Synopsis
- Senescent B cells accumulate in the adipose tissue of individuals with obesity and contribute to inflammation through the secretion of inflammatory mediators and markers associated with the senescence-associated secretory phenotype (SASP).
- The study aims to investigate the effects of Metformin (MET), a common diabetes medication, on these senescent B cells to see if it can decrease their numbers, inflammatory secretion, and metabolic needs in vitro.
- Results indicate that MET treatment effectively reduces both the frequency of senescent B cells and their secretion of inflammatory cytokines, suggesting potential therapeutic benefits for managing inflammation in obesity.