Dissolving microneedles for brain delivery: Recent advances and challenges.

Over the past decade, dissolving microneedles (DMNs) have emerged as a promising approach for drug delivery to the brain. They are tiny devices designed to penetrate biological barriers, offering a painless method for localized and controlled drug delivery. They are suitable for delivering drugs that are susceptible to degradation when delivered orally.

Biomedical implication of microfluidics in disease diagnosis and therapeutics: from fabrication to prognosis.

Microfluidics has given us an approach to regulate the fluids' behaviour and influence at the microscale level, including the microchannels as an integral element. Microchannels encompass the high surface area-to-volume ratio, causing the rapid diffusion and mixing of substances within the tiny canals and facilitating predictable and stable fluid dynamics. This precise regulatory mechanism of fluid behaviour by microchannels is significant for several biological and chemical processes.

Prenatal arsenic exposure alters EZH2/H3K27me3 to induce RKIP/NF-kB/ERK1/2-mediated early-onset kidney disease in mouse offspring.

The rising incidences of chronic kidney disease (CKD) and renal failure are a major public health concern. Arsenic, a widespread water contaminant and environmental toxicant, is well-known to contribute to kidney disease in adults. However, its long-term effects on kidney health following early-life exposure remain poorly understood.

Deciphering aptamer-protein interactions for bovine sperm sorting through in silico and in vitro studies.

Background: In recent years, aptamers have emerged as versatile molecular tools with promising applications in various fields, including diagnostics and therapeutics. In livestock reproduction, their application holds promise for improving the sorting and identification of X and Y chromosome-bearing sperm cells, which is essential for increasing productivity in the dairy and beef industries.

Method: This study utilized seven rounds of Cell-SELEX using bovine X and Y sperm cells to isolate specific aptamers that target these cells.

Computational Cellular Mathematical Model Aids Understanding the cGAS-STING in NSCLC Pathogenicity.

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. According to 2020 reports, globally, 2.2 million cases are reported every year, with the mortality number being as high as 1.