Influence of electroporation parameters on the reaction and transport mechanisms in electro-chemotherapeutic treatments using Boolean modeling and the Method of Fundamental Solutions.

The systemic administration of chemotherapeutic drugs involves some reaction and transport mechanisms (RTMs), including perfusion along the blood vessels, extravasation, lymphatic drainage, interstitial and transmembrane transport, and protein association and dissociation, among others. When tissue is subjected to the controlled application of electric pulses (electroporation), the vessel wall and cell membrane are permeabilized, capillaries are vasoconstricted and tissue porosity is modified, affecting the RTMs during electro-chemotherapeutic treatments. This study is a theoretical investigation about the influence of the electric field magnitude (E), number of electroporation treatments (N) and duration of each electroporation protocol (T) on the presence, interaction and rates of the RTMs using in-house computational tools.

Assessing deoxynivalenol concentration reduction and mass loss in wheat batches using near infrared hyperspectral imaging.

Deoxynivalenol is a mycotoxin which frequently contaminates wheat and its derived products causing a major concern. In this work a previously developed model was inserted into a prototype desktop application for automated prediction of individual wheat kernels as contaminated over or under the maximum set level in the EU. Using 42 batches to test the system it was observed that in batches contaminated over 1 mg/kg the rejected fraction always contained more deoxynivalenol (mean 8.

The success of insulin pump therapy: importance of education of patients and health professionals.

Unlabelled: The purpose of the study is to investigate the importance of education and re-education for the proper use of the insulin pump (IP) in order to maintain stable glycemic control over an extended period.

Methods: The study was designed as a cross-sectional retrospective study. A total of 168 patients participated in a five-day structured education program in a small group.