Publications by authors named "S R M S Esteves"
The role of luteinizing hormone activity in spermatogenesis: from physiology to clinical practice.
Reprod Biol Endocrinol
January 2025
The production of spermatozoa, a process known as spermatogenesis, is primarily controlled by follicle-stimulating hormone (FSH) and luteinizing hormone (LH)-driven testosterone. LH acts on the Leydig cells, stimulating steroid production, predominantly testosterone, and activating critical inter-related spermatogenesis regulatory pathways. Despite evidence that exogenous gonadotropins containing LH activity can effectively restore spermatogenesis in males with hypogonadotropic hypogonadism, the use of these drugs to treat other forms of male infertility is the subject of an ongoing debate.
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- - The study aimed to identify serum anti-Müllerian hormone (AMH) and antral follicle count (AFC) thresholds that signal a higher risk of hyper-response to ovarian stimulation in women undergoing their first IVF cycle, following the HERA definition.
- - A total of 4220 women were analyzed, revealing thresholds of AMH≥4.38ng/mL and AFC≥16 for the overall cohort, with varying thresholds based on age groups.
- - The findings highlighted that factors like AMH, AFC, and age significantly predict the likelihood of hyper-response during ovarian stimulation, with older women requiring more hormonal treatment.
Article Synopsis
- This study investigates whether daily subcutaneous administration of 25 mg progesterone improves the chances of live birth in women with low serum progesterone levels (7-10 ng/mL) before a frozen embryo transfer (FET).
- A cohort of 192 women was divided into three groups based on their progesterone levels and whether they received the rescue treatment, with the main focus on comparing live birth rates (LBR) among these groups.
- The results showed that the live birth rates were similar across the groups, indicating that adding the progesterone rescue treatment does not significantly improve outcomes for patients with low serum progesterone levels.