Publications by authors named "S R M Madiraju"
Angiopoietin-like protein 8 (Angptl8), expressed in the liver and adipocytes, forms a complex with Angptl3 or Angptl4, which regulates lipoprotein lipase and triglyceride metabolism. However, the precise functions of adipocyte Angptl8 remain elusive. Here we report that adipocyte-specific inducible Angptl8-knockout (AT-A8-KO) male mice on normal diet showed minor phenotypic changes, but after a high-fat high fructose (HFHF) diet, exhibited decreased body weight gain and glycemia, elevated rectal temperature and early dark phase energy expenditure compared to the Cre controls.
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- The study explores the role of glycerol-3-phosphate phosphatase (G3PP) in male fertility, highlighting its crucial expression in the testis and sperm, especially during spermatogenesis.
- Researchers found that male mice lacking G3PP (cG3PP-KO) are infertile due to dysfunctional sperm with poor motility and increased oxidative stress, while a tamoxifen-inducible version (icG3PP-KO) maintained some fertility due to a small number of normal sperm.
- The results suggest that G3PP is vital for sperm function and health, as its absence leads to abnormal sperm production and metabolism, impacting overall male fertility.
In this case report, we present two clinical cases of penile strangulation caused by a bottleneck at the base of the penis. In the first case, corporal aspiration was used to decrease the blood that is trapped in the corpora due to the constriction. A rotating saw was used to incise the bottleneck in a full-thickness manner.
View Article and Find Full Text PDFLess than 1 % of melanomas metastasize to the genitourinary system. Pseudomelanosis is a rare benign condition due to deposition of melanin-like pigment. We present a 44-year-old male with metastatic melanoma to the left ureter accompanied by pseudomelanosis vesica.
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