Immediate second resection versus restage transurethral resection of bladder tumor: A prospective randomized clinical trial (IMMERSE trial).

Background: The role of repeat transurethral resection of bladder tumor (TURBT) for the management of nonmuscle invasive bladder carcinoma is debated, especially when initial resections include detrusor muscle. This study compares immediate second resection (additional deep biopsies in the same session) with standard restage TURBT performed 2-6 weeks post-initial TURBT to determine adequacy in detrusor muscle sampling and compare the disease rate at restage TURBT in both groups.

Material And Methods: A randomized trial was conducted at a tertiary care hospital, including patients aged ≥18 years undergoing TURBT with complete primary tumor resection.

Association between oral microbiome dysbiosis and Sjogren Syndrome. A systematic review of clinical studies.

Objectives: This systematic review investigates the association of oral microbiome dysbiosis with Sjogren Syndrome (SS).

Materials And Methods: Indexed databases (PubMed/Medline, EMBASE, OVID, Web of Science, and Scopus) were independently searched for relevant manuscripts published until August 2024. Clinical studies on oral microbial flora count and diversity in SS patients were included.

Combined effects of climate stressors and soil arsenic contamination on metabolic profiles and productivity of rice (Oryza sativa L.).

Rice productivity and quality are increasingly at risk in arsenic (As) affected areas, challenge that is expected to worsen under changing climatic conditions. Free-Air Concentration Enrichment experiments revealed that eCO, eO, and eTemp, whether acting individually or in combination with low and high As irrigation, significantly impact rice yield and grain quality. Elevated CO₂ significantly increased shoot biomass, with minimal impact on root biomass, except under low As irrigation conditions.

Evaluation of Multi-Lingual Simplifications of IR Procedural Reports Using GPT-4.

This study assesses the feasibility of Large Language Models like GPT-4 (OpenAI, San Francisco, CA, USA) to summarize interventional radiology (IR) procedural reports to improve layperson understanding and translate medical texts into multiple languages. 200 reports from eight categories were summarized using GPT-4. Readability was assessed with Flesch-Kincaid Reading Level (FKRL) and Flesch Reading Ease Score (FRES).

From Plant to Pathway: Molecular Mechanisms of Ruscogenin in Preventing Amyloid-Beta Aggregation through Computational and Experimental Approaches.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, extracellular amyloid-β (Aβ) plaque accumulation, and intracellular neurofibrillary tangles. Recent efforts to find effective therapies have increased interest in natural compounds with multifaceted effects on AD pathology. This study explores natural compounds for their potential to mitigate AD pathology using molecular docking, ADME screening, and assays, with ruscogenin─a steroidal sapogenin from emerging as a promising candidate.