Publications by authors named "S R Krishna Manohar"

Most of our movement consists of sequences of discrete actions at regular intervals-including speech, walking, playing music, or even chewing. Despite this, few models of the motor system address how the brain determines the interval at which to trigger actions. This paper offers a theoretical analysis of the problem of timing movements.

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The world faces a global challenge of how to meet the nutritional needs of a diverse global population through diets. This paper defines the relative nutritional needs across each stage of the life cycle to support human health and identifies who is nutritionally vulnerable. Findings in this paper suggest that there are biological nutritional vulnerabilities stemming from high micronutrient needs per calorie in certain phases of the life cycle, particularly for infants and young children, women of reproductive age, pregnant and lactating women, and older adults, particularly older women.

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A growing evidence base suggests that the integration of museum-based activities into health professions education can contribute to learner resilience and wellbeing, promote capacity for patient-centered care, and encourage equity in learning environments. However, the styles and methods for implementing museum-based programs vary widely across different institutions. This retrospective leverages the lessons learned from 5 years of experience implementing museum-based programs at one large academic institution to examine the various operational and logistical considerations in implementing a museum-based program for health professions learners.

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Motivation depends on dopamine, but might be modulated by acetylcholine which influences dopamine release in the striatum, and amplifies motivation in animal studies. A corresponding effect in humans would be important clinically, since anticholinergic drugs are frequently used in Parkinson's disease, a condition that can also disrupt motivation. Reward and dopamine make us more ready to respond, as indexed by reaction times (RT), and move faster, sometimes termed vigour.

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Article Synopsis
  • Donepezil and memantine are second-generation medications used for managing mild to moderate Alzheimer's disease, acting on different neural pathways to help with cognitive decline.
  • Donepezil inhibits acetylcholinesterase, while memantine blocks NMDA receptors, both targeting the central nervous system.
  • A case study of an 81-year-old male with Alzheimer's and schizophrenia revealed he developed a second-degree atrioventricular block after taking these drugs, but his condition improved within 2 to 3 weeks after stopping the medications and receiving short-term treatment.
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