Publications by authors named "S R Kandan"
Calcific versus non-calcific plaque: a CAD-RADS and FFRCT study.
Int J Cardiovasc Imaging
January 2025
Article Synopsis
- The study focused on the CAD-RADS system to standardize CTCA reporting and explored how coronary calcification affects the assessment of stenosis in patients.
- Researchers hypothesized that the Fractional Flow Reserve (FFRCT) would be lower for calcified stenoses (Ca+) compared to non-calcified ones (Ca-) in the same CAD-RADS categories.
- Results showed that there was no significant difference in FFRCT values between Ca+ and Ca- stenoses for most categories, but CAD-RADS 3 Ca+ had lower FFRCT readings, suggesting possible underestimation that was not confirmed with invasive tests.
Hepatopancreatic microsporidiosis (HPM) caused by Enterocytozoon hepatopenaei (EHP) is a disease of utmost concern in almost all shrimp growing countries. The pathogen was characterized by ultramicrography, histopathology and phylogenetic analysis of 18srDNA. A total of 183 biological samples were collected from all major shrimp growing states of the country.
View Article and Find Full Text PDFBackground: The world symposium on pulmonary hypertension (PH) has proposed that PH be defined as a mean pulmonary artery pressure (mPAP) > 20 mmHg as assessed by right heart catheterisation (RHC). Transthoracic echocardiography (TTE) is an established screening tool used for suspected PH. International guidelines recommend a multi-parameter assessment of the TTE PH probability although effectiveness has not been established using real world data.
View Article and Find Full Text PDFNicotinamide N-methyltransferase (NNMT) is a metabolic regulator that catalyzes the methylation of nicotinamide (Nam) using the co-factor S-adenosyl-L-methionine to form 1-methyl-nicotinamide (MNA). Overexpression of NNMT and the presence of the active metabolite MNA is associated with a number of diseases including metabolic disorders. We conducted a high-throughput screening campaign that led to the identification of a tricyclic core as a potential NNMT small molecule inhibitor series.
View Article and Find Full Text PDFAim: To quantify the real-world clinical and cost impact of computed tomography (CT) coronary angiography (CTCA)-derived fractional flow reserve (FFR) in the National Health Service (NHS).
Materials And Methods: Consecutive clinical CTCA examinations from September to December 2018 with ≥1 stenosis of ≥25% underwent FFR analysis. The Heart Team reviewed clinical data and CTCA findings, blinded to FFR values, and documented hypothetical consensus management.