Dosimetry and Toxicity Comparison of Three-Dimensional Conformal Radiation Therapy and Intensity-Modulated Radiation Therapy in Locally Advanced Lung Cancer Across a Large Statewide Quality Collaborative.

Purpose/objective(s): Use of intensity-modulated radiation therapy (IMRT) versus three-dimensional conformal external beam radiation therapy (3D-CRT) for definitive chemoradiation therapy (CRT) in locally advanced non-small cell lung cancer (LA-NSCLC) has been associated with decreased late pneumonitis, decreased high dose to the heart (itself associated with improved overall survival), and improved patient quality of life. In a statewide radiation oncology quality consortium, we sought to evaluate the impact of IMRT versus 3D-CRT treatment technique on dosimetry and toxicity.

Materials/methods: From 2012 to 2022, 1746 LA-NSCLC patients meeting inclusion criteria underwent definitive RT (90% CRT) with either 3D-CRT (n=313) or IMRT (n=1433) and were enrolled in the [quality consortium] prospective, multicenter statewide initiative.

Reirradiation Special Medical Physics Consultations: Lessons Learned from Nearly 3000 Courses of Treatment.

Introduction: Reirradiation (reRT) has become increasingly prevalent due to an aging population and advancements in cancer detection and treatment. However, the field is still lacking standardized dosimetric evaluation methods and reRT workflows, which leads to difficulty in correlating clinical outcomes with delivered dose. This study reports on the implementation and evolution of a standardized reRT workflow in the Department of Radiation Oncology at [redacted], describing insights gained from nearly 3000 external beam reirradiation courses delivered since 2017.

Side-Branch Intravascular Lithotripsy for an Uncrossable Chronic Total Occlusion.

This case describes percutaneous coronary intervention of a chronic total occlusion of the right coronary artery at the RV marginal bifurcation that was wire-uncrossable until plaque modification with side branch intravascular lithotripsy into the right ventricular marginal allowed crossing.

Modeling the focusing of a radially polarized laser beam with an initially flat-top intensity profile.

Radially polarized light beams present very interesting and useful behavior for creating small intensity spots when tightly focused, and manipulating nanostructures or charged particles via their longitudinal field. The modeling of the propagation of such vector beams, however, is almost always done using the lowest-order fundamental radially polarized beam or a single higher-order mode due to the complexity of vector diffraction theory. We show how a flat-top radially polarized beam, relevant for high-power lasers, can be modeled analytically using a sum of higher-order beams, describe a number of interesting qualities of such beams, and compare to numerically solved integral descriptions.