Publications by authors named "S R Je"
Background And Purpose: Parkinson's disease (PD) significantly impacts the quality of life via both motor and nonmotor symptoms. Exercise is a valuable nonpharmacological intervention that can alleviate PD symptoms and slow disease progression. Understanding the factors that motivate and restrict exercise in PD patients is essential for promoting engagement.
View Article and Find Full Text PDFBackground: Current Pediatric Advanced Life Support Guidelines recommend maintaining blood pressure (BP) above the 5th percentile for age following return of spontaneous circulation (ROSC) after cardiac arrest (CA). Emerging evidence suggests that targeting higher thresholds, such as the 10th or 25th percentiles, may improve neurologic outcomes. We aimed to evaluate the association between post-ROSC BP thresholds and neurologic outcome, hypothesizing that maintaining mean arterial pressure (MAP) and systolic blood pressure (SBP) above these thresholds would be associated with improved outcomes at hospital discharge.
View Article and Find Full Text PDFDistinct roles of centriole distal appendage proteins in ciliary assembly and disassembly.
Cell Commun Signal
December 2024
The primary cilium is a cellular organelle whose assembly and disassembly are closely linked to the cell cycle. The centriole distal appendage (DA) is essential for the early stages of ciliogenesis by anchoring the mother centriole to the cell surface. Despite the identification of over twelve proteins constituting the DA, including CEP83, CEP89, CEP164, FBF1, and SCLT1, their specific functions in ciliary dynamics are not fully understood.
View Article and Find Full Text PDFArticle Synopsis
- - This study focused on analyzing the relationship between cumulative exposures of oxygen (PaO) and carbon dioxide (PaCO) in children who had a return of circulation after cardiac arrest, looking specifically at their survival rates and neurological outcomes within 24 hours post-event.
- - Data were collected from pediatric resuscitation sites and included children aged 1 day to 17 years, with a total of 292 participants. The study excluded cases with congenital cyanotic heart disease.
- - Results showed that while 57% of the children survived to discharge and 48% had favorable neurological outcomes, the cumulative PaO and PaCO exposure was not significantly related to these outcomes; only 24% and 58% of patients adhered to AHA
Simultaneous co-circulation of two genotypes of dengue virus serotype 3 causing a large outbreak in Sri Lanka in year 2023.
J Infect Dis
October 2024
Background: We observed a discrepancy between dengue NS1 antigen test and molecular diagnostics, with the emergence of (DENV) serotype 3 in Sri Lanka and sought to understand the cause for the rise in cases and high failure rates of molecular diagnostics.
Methods: Whole genomic sequencing was carried out in 22 DENV-3 samples. Phylogenetic and molecular clock analysis were done for genotype assignment and to understand the rate of evolution.