Publications by authors named "S R Jadcherla"
Preterm birth is the leading cause of neonatal and under-5 mortality globally, and healthcare-related burden and nutrition-related morbidities are unsustainable, particularly in resource-limited regions. Additionally, preterm infants are susceptible to multiple adverse outcomes including growth faltering, suboptimal neurodevelopment, and multisystemic morbidities. Maturation, healing, repair, and restoration to normalcy in preterm-born infants require optimizing nutrition; only then, prognosis, growth, neurodevelopment, and overall quality of life can improve.
View Article and Find Full Text PDFPrematurity presents numerous barriers to mother's own milk (MOM) feeding and direct breastfeeding (DBF). This study aimed to determine factors associated with MOM feeding and DBF at discharge from the neonatal intensive care unit (NICU) in preterm-born infants presenting with feeding difficulties. A retrospective study of data from 237 preterm-born infants referred for evaluation of feeding difficulties and discharged home on full oral feeds was examined.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to investigate swallowing biomarkers in infants during oral feeding, focusing on differences between those fed completely orally and those partially orally fed, while conducting pH-impedance testing.
- - A total of 40 infants were analyzed, measuring various swallowing metrics and finding significant differences in volume consumption, consumption rate, and hospital stays between the two feeding groups, along with a notable relationship between acid reflux index (ARI) and swallowing frequency.
- - Results indicated that while partially oral-fed infants had less gastroesophageal reflux (GER), those with higher ARI demonstrated increased swallowing rates and better oral intake, suggesting the importance of consistent feeding in stimulating effective swallowing responses.
Feeding/swallowing and airway protection are complex functions, essential for survival, and continue to evolve throughout the lifetime. Medical and surgical advances across the globe have improved the long-term survival of medically complex children at the cost of increasing comorbidities, including dysfunctional swallowing (dysphagia). Dysphagia is prominent in children with histories of preterm birth, neurologic and neuromuscular diagnoses, developmental delays, and aerodigestive disorders; and is associated with medical, health, and neurodevelopmental problems; and long-term socioeconomic, caregiver, health system, and social burdens.
View Article and Find Full Text PDFImportance: Maternal milk feeding of extremely preterm infants during the birth hospitalization has been associated with better neurodevelopmental outcomes compared with preterm formula. For infants receiving no or minimal maternal milk, it is unknown whether donor human milk conveys similar neurodevelopmental advantages vs preterm formula.
Objective: To determine if nutrient-fortified, pasteurized donor human milk improves neurodevelopmental outcomes at 22 to 26 months' corrected age compared with preterm infant formula among extremely preterm infants who received minimal maternal milk.