Publications by authors named "S R Frolova"
Article Synopsis
- Marfan syndrome (MFS) is a rare genetic disorder that affects connective tissue, leading to serious complications like thoracic aortic aneurysms (TAA), which may require preventive surgery.
- There is a need for non-invasive biomarkers and new therapeutic targets for MFS, as current monitoring methods involve complex imaging and are time-sensitive.
- Recent studies using high-throughput platforms have identified potential biomarkers and therapeutic targets related to pathways involved in MFS, but further validation in large patient groups is needed to confirm their effectiveness.
Fusarium basal rot of onions causes large losses during storage of commercial production of onion bulbs, which in turn adversely affects the food market situation in the off-season period. There are no data on the composition of spp., which causes onion basal rot in the Russian Federation.
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- * Two key regions, Krasnodar Krai and Crimea, were studied, revealing different species compositions and their impacts on pepper wilting in each area.
- * The findings highlight previously unrecognized species as potential causes of wilt, which can inform biological control strategies and aid in developing pepper varieties resistant to this disease.
Voltage-gated Na channels are crucial to action potential propagation in excitable tissues. Because of the high amplitude and rapid activation of the Na current, voltage-clamp measurements are very challenging and are usually performed at room temperature. In this study, we measured Na current voltage-dependence in stem cell-derived cardiomyocytes at physiological temperature.
View Article and Find Full Text PDFThe World Health Organization (WHO) reports that tuberculosis (TB) is one of the top 10 leading causes of global mortality. The increasing incidence of multidrug-resistant TB highlights the urgent need for an intensified quest to discover innovative anti-TB medications In this study, we investigated four new derivatives from the quinoxaline-2-carboxylic acid 1,4-dioxide class. New 3-methylquinoxaline 1,4-dioxides with a variation in substituents at positions 2 and 6(7) were synthesized via nucleophilic aromatic substitution with amines and assessed against a spp.
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