Estimation of the wetting induced settlement of loess soils from the wetting soil-water characteristic curve.

Collapsible loess soils, known for their significant volume reduction upon the wetting, pose critical challenges in the geotechnical engineering. The estimation of the wetting-induced settlement is crucial for the foundation design and the determination of the negative skin friction on the pile. In this paper, a new method is proposed to estimate the wetting induced collapse from the wetting soil-water characteristic curve (SWCC) and the index properties of the loess soils.

Driving mechanism of urban expansion in the Bohai Rim urban agglomeration from the perspective of spatiotemporal dynamic analysis.

The urban agglomeration represents the predominant form of new urbanisation, yet the evolution of its internal spatial structure exhibits pronounced spatial and temporal heterogeneity. This study concentrates on the Bohai Rim urban agglomeration, one of three major urban agglomerations in China, which has received comparatively limited research attention but has also undergone substantial urbanisation. Therefore, we reassessed and explored the spatial-temporal evolution of the spatial structure of urban expansion using Exploratory Spatiotemporal Data Analysis (ESTDA), and summarized the driving mechanisms using Geographically and Temporally Weighted Regression (GTWR).

Lactoferrin targeting INTL1 receptor inhibits hepatocellular carcinoma progression via apoptosis and cell cycle signaling pathways.

Hepatocellular carcinoma (HCC) constitutes 90% of liver cancer cases and ranks as the third leading cause of cancer-related mortality, necessitating urgent development of alternative therapies. Lactoferrin (LF), a natural iron-binding glycoprotein with reported anticancer effects, is investigated for its potential in liver cancer treatment, an area with limited existing studies. This study focuses on evaluating LF's anti-liver cancer effects on HCC cells and assessing the preventive efficacy of oral LF administration in a murine model.

THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer.

Cancer-associated fibroblasts (CAFs) exert multiple tumor-promoting functions and are key contributors to drug resistance. The mechanisms by which specific subsets of CAFs facilitate oxaliplatin resistance in colorectal cancer (CRC) have not been fully explored. This study found that THBS2 is positively associated with CAF activation, epithelial-mesenchymal transition (EMT), and chemoresistance at the pan-cancer level.

The relationship between serum uric acid and homocysteine is influenced by kidney function.

Background And Aim: Prior research has established a relationship between homocysteine (Hcy) and serum uric acid (SUA) levels; however, the precise mechanisms underlying this association remain unclear. The objective of this research was to explore the correlation between SUA and Hcy and to evaluate the possible role of kidney function as a mediator in the connection between SUA and Hcy.

Methods And Results: Consecutive enrollment of 16870 participants aged 20-60 years was conducted at the Third Xiangya Hospital of Central South University.