Publications by authors named "S R Disha"
Bacteriophages, the most abundant biological agents targeting bacteria, offer a promising alternative to antibiotics for combating multi-drug resistant pathogens like Acinetobacter baumannii. However, the rapid development of bacteriophage resistance poses a significant challenge. This study highlights the contribution of outer membrane proteins (OMPs) in the emergence of bacteriophage resistance in A.
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- Aeromonas hydrophila is a harmful pathogen in aquaculture, causing economic losses, but recent advancements in nanotechnology could help create effective vaccines.
- This study examined a vaccine using nanoparticle-loaded outer membrane protein A (OmpA) from A. hydrophila, showing good size and encapsulation efficiency with promising results in zebrafish models.
- The oral administration of the nanoparticle vaccine led to a 77.7% survival rate in infected zebrafish, suggesting it stimulates a strong immune response and offers significant protection against the pathogen.
Pancreatic tuberculosis (TB) warrants heightened suspicion in individuals with pancreatic lesions and risk factors such as HIV, organ transplantation, or pertinent immigration history. We present a 38-year-old man who presented with hemodynamically unstable gastrointestinal bleeding. He was found to have pancreatic TB complicated by a duodenal ulcer with fistula.
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- * Researchers are exploring the oral delivery of a vaccine using nano-biotechnology, specifically focusing on the outer membrane protein maltoporin as a potential candidate.
- * The study demonstrates successful encapsulation of maltoporin in a biodegradable polymer, resulting in a promising delivery system that could effectively trigger immune responses in fish through oral administration.
In this study, we have introduced a method for the synthesis of various metal-doped nano-crystalline hydroxyapatites (HAp) using a standard wet chemical precipitation technique. Both divalent (Ni and Zn) and trivalent (Al and Fe) metals were selected for the doping process. Additional research work was also conducted to assess the antimicrobial efficacy of these doped-HAps against a range of gram-positive and gram-negative microorganisms.
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