An organogold compound impairs Leishmania amazonensis amastigotes survival and delays lesion progression in murine cutaneous leishmaniasis: Mechanistic insights.

Leishmaniasis is one of the most important neglected diseases, classically characterized by three clinical forms that if left untreated can lead to skin lesions, lifelong scarring, or death depending on the parasite species. Unfortunately, treatment is unsatisfactory and the search for an improved therapy has been a priority. Gold compounds have emerged as promising candidates and among them, Au(I)bis-N-heterocyclic carbene (Au(BzTMX)) has stood out.

Internalization and Cellular Fate of Protein Corona-Coated Nanoparticles by Multimodal Multi-Scale Microscopy.

Upon exposure to biological environments, nanoparticles are rapidly coated with biomolecules, predominantly proteins, which alter their colloidal stability, biodistribution, and cell interactions. Despite extensive efforts to investigate the nanoparticles' fate, only a few studies use high-resolution characterization methods that allow in-depth characterization, and the existing methodologies are unable to differentiate particles internalized at the onset of incubation from those taken up toward the end of an incubation period. In this study, these limitations related to incubation disparities are overcame and precisely monitored the spatiotemporal displacement of colloidally stable protein corona-coated nanoparticles within cells.

Energy and environmental assessment of solid recovered fuels valorisation: Waste-to-Chemicals options vs co-combustion in cement plants.

The increasing interest in Waste-to-Chemical (WtC) technologies operating with Solid Recovered Fuels (SRF) from non-recyclable plastic streams requires a quantitative analysis on the actual convenience of this alternative valorization pathway. This study assesses SRF in selected WtC technologies for hydrogen and methanol production and compares it with the well-established practice of co-combustion in the cement industry. Two case studies are considered: the first one represents the current scenario where SRF is used in co-combustion for cement production meanwhile the chemical is produced by steam reforming; in the second scenario, the cement plant is fed with pet-coke only, leaving SRF as a feedstock for WtC.

NEK10 kinase ablation affects mitochondrial morphology, function and protein phosphorylation status.

Background: NEK10, a serine/threonine/tyrosine kinase belonging to the NEK (NIMA-related kinases) family, has been associated with diverse cellular processes. However, no specific target pathways have been identified. Our previous work knocking down NEK10 in HeLa cells suggested a functional association with mitochondria, as we observed altered mitochondrial morphology, mitochondrial oxygen consumption, mtDNA integrity, and reactive oxygen species levels.

Correction: Zanchetta et al. Effects of Electrospun Fibrous Membranes of PolyCaprolactone and Chitosan/Poly(Ethylene Oxide) on Mouse Acute Skin Lesions. 2020, , 1580.

In the original publication, the authors claimed that Figure 6 reporting Western blot data was erroneous as published [...